sp1 transcription factor การใช้

• The SP1 transcription factor stimulates the transcription of MTA3.
• Butyrate inhibits angiogenesis by inactivating Sp1 transcription factor activity and downregulating vascular endothelial growth factor gene expression.
• GABPA has been shown to interact with Host cell factor C1, Sp1 transcription factor and Sp3 transcription factor.
• Expression of MTA2 is stimulated by Sp1 transcription factor and repressed by ?-defensins in colon cancer cells.
• Withaferin A, a sterodial lactone from " Withania Somnifera " plant is known to inhibit Sp1 transcription factor.
• There are also several sets of repeats, sequences resembling the Sp1 transcription factor binding site, and two cAMP receptor binding sites upstream of the cap.
• CYP2J2 * 7 (  " 76G > T, rs890293, upstream Promoter ( genetics ) site ) has decreased binding of the Sp1 transcription factor resulting in its lowered expressionas and lowered levels of EETs in plasma.
• For example, a mutation of MDM2 has been found in stomach cancer, renal cell carcinoma, and liver cancer ( amongst others ) to deregulate MDM2 concentrations by increasing its promoter s affinity for the Sp1 transcription factor, causing increased transcription of MDM2 mRNA.
• The human GALK1 gene contains 8 exons and spans approximately 7.3 kb of genomic DNA . The GALK1 promoter was found to have many features in common with other housekeeping genes, including high GC content, several copies of the binding site for the Sp1 transcription factor and the absence of TATA-box and CCAAT-box motifs typically present in eukaryotic polymerase II promoters.
• :: : : Yes, the problem with eating sugars has more to do with not getting enough fibers as a result and fibers are the food for gut bacteria who convert it to Short-chain fatty acids which we need : " The short-chain fatty acid butyrate is particularly important for colon health because it is the primary energy source for colonic cells and has anti-carcinogenic as well as anti-inflammatory properties [ 7 ] that are important for keeping colon cells healthy . [ 8 ] [ 9 ] Butyrate inhibits the growth and proliferation of tumor cell lines in vitro, induces differentiation of tumor cells, producing a phenotype similar to that of the normal mature cell, [ 10 ] and induces apoptosis or programmed cell death of human colorectal cancer cells . [ 11 ] [ 12 ] Butyrate inhibits angiogenesis by inactivating Sp1 transcription factor activity and downregulating VEGF gene expression . [ 13 ] " talk ) 20 : 19, 20 September 2016 ( UTC)